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OP‑CHOL — Carbachol Intraocular Solution 0.01% | Agaaz Ophthalmics
INTRAOCULAR MIOTIC
MiosisSterileIntraoperative

OP‑CHOLCarbachol Intraocular Solution 0.01%

Intraoperative miotic engineered for controlled pupillary constriction at the close of cataract surgery — supporting stable wound closure, IOL centering, and post-operative IOP management.

0.01%
Carbachol
2–3 min
Onset of Miosis
≤24 hr
Duration
MIOSIS — PUPIL CONSTRICTION
OP-CHOL Carbachol Intraocular Solution by Agaaz Ophthalmics
Rapid Miosis2–3 min onset
Dual ReceptorMuscarinic + Nicotinic
≤24 hr DurationSustained effect
Carbachol 0.01%Intraoperative MioticPupil ConstrictionIOP ManagementDual Receptor AgonistSterile Single-UseEnd-of-Case StepCarbachol 0.01%Intraoperative MioticPupil ConstrictionIOP ManagementDual Receptor AgonistSterile Single-UseEnd-of-Case Step
CLINICAL PURPOSE

A controlled finish
to every cataract case.

OP‑CHOL is built for the critical last step — achieving rapid, predictable pupillary constriction that supports wound stability, IOL positioning, and post-operative IOP control.

Rapid Pupil Control

Achieves prompt miosis within 2–3 minutes of intracameral injection — providing the surgeon immediate pupillary constriction when needed.

IOP Reduction

Reduces the intensity of intraocular pressure elevation in the first 24 hours after cataract surgery — a clinically meaningful post-operative benefit.

Sustained Duration

Unlike acetylcholine which lasts minutes, carbachol provides miosis lasting up to 24 hours — reducing the need for supplementary miotics post-operatively.

Wound Stability

A constricted pupil at the close of surgery helps prevent iris prolapse, supports self-sealing wound architecture, and assists IOL centration.

MECHANISM OF ACTION

How OP‑CHOL achieves
pupillary constriction.

Carbachol is a parasympathomimetic that directly activates acetylcholine receptors in the iris sphincter muscle, producing rapid and sustained miosis.

STEP 01

Intracameral Injection

OP‑CHOL is injected gently into the anterior chamber parallel to the iris face and tangential to the pupil border at the conclusion of cataract surgery.

STEP 02

Dual Receptor Activation

Carbachol directly stimulates both muscarinic and nicotinic acetylcholine receptors on the iris sphincter muscle — a dual mechanism providing more sustained effect than acetylcholine alone.

STEP 03

Iris Sphincter Contraction

Receptor activation triggers contraction of the circular iris sphincter muscle fibres, producing concentric pupillary constriction (miosis) within 2–3 minutes.

STEP 04

Sustained Miosis + IOP Control

The miotic effect is maintained for up to 24 hours. Simultaneously, increased aqueous humour outflow helps reduce post-operative IOP elevation — a dual clinical benefit.

SPECIFICATIONS

Key parameters at a glance.

Brand
OP‑CHOL
Intraoperative miotic
Generic
Carbachol
Cholinergic agonist
Strength
0.01%
Intraocular solution
Use
Intraoperative
End-of-case miosis
FREQUENTLY ASKED QUESTIONS

Common questions about
carbachol and OP‑CHOL.

What is carbachol intraocular solution used for?
Carbachol intraocular solution 0.01% is used during cataract surgery to induce miosis (pupil constriction) after IOL implantation. It helps achieve a controlled, stable pupil for wound closure, prevents iris entrapment at incision sites, and reduces post-operative IOP elevation in the first 24 hours.
How does carbachol work to constrict the pupil?
Carbachol is a parasympathomimetic agent that directly stimulates both muscarinic and nicotinic acetylcholine receptors in the iris sphincter muscle. This dual-receptor activation causes rapid and sustained pupillary constriction. Onset is typically 2–3 minutes with intraocular injection, and miotic effect lasts up to 24 hours.
How is carbachol different from acetylcholine as an intraoperative miotic?
Both achieve miosis, but carbachol has a longer duration (up to 24 hours vs minutes for acetylcholine), activates both muscarinic and nicotinic receptors, and studies show carbachol is less toxic to corneal endothelium. Carbachol also reduces IOP elevation in the first 24 hours post-surgery.
Who manufactures OP‑CHOL?
OP‑CHOL is manufactured by Agaaz Ophthalmics, an Indian manufacturer and global exporter of ophthalmic surgical products including IOLs, viscoelastics, solutions, instruments, and diagnostic consumables.

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